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Ketamine Treatments

Ketamine is a safe anesthetic agent approved by the FDA since the 1960s and since then thousands of hospitals around the world have used this innovative treatment. It is on the List of Essential Medicines by the World Health Organization due to its safety and efficiency.

Ketamine Therapy is primarily used to treat various mental health conditions, and it has shown promise in managing symptoms for conditions such as…

Intranasal ketamine is one of the ways The Crane Center works with patients in need of this type of treatment. We also have intramuscular options. Your doctor will work with you to determine which route of administration may be most effective. 

Ketamine therapy must be delivered in a controlled healthcare environment where patients will be observed for up to two hours.

Ketamine Treatment for depression is available for adults 18 and over who suffer moderate to severe depression and who have not thrived in traditional therapies for depression.

In addition to evaluating your medical history and lab tests, our thorough review will make sure ketamine therapy is the appropriate treatment for you.

Ketamine treatment dosages for depression are significantly lower and relatively safer than the anesthesia dosages.

However, the risks are changes to your blood pressure and heart rate, which we will closely monitor during treatment.

We will also watch for any long-term risks including urinary symptoms, cognitive impairment (long-term use), and substance disorders.

Ketamine interacts with neurotransmitter glutamate as a dissociative agent. The effect on serotonin and the opiate system is also downfield. Research has shown that it can significantly reduce suicidal thoughts in 24 hours.

The American Psychiatry Journal found that major depressive disorder symptoms can be reversed within 24 hours with no harsh secondary effects, such as memory loss. The effect of a ketamine infusion therapy can be sensed within 40 minutes of the first dose.

Of all mental health disorders, bipolar disorder has one of the highest lifetime risks of suicide. Ketamine has been approved for the treatment of acute suicidal ideation, which means it may be appropriate for bipolar patients. Effectively treating the more urgent symptoms of bipolar, such as thoughts of suicide, would be an important step in lifelong management of the disorder. 

Ketamine is also FDA-approved in the treatment of refractory depression. Depressive episodes are part and parcel of both types of Bipolar, and these episodes can be severe. The increased suicide risk of depressed bipolar patients warrants an effective treatment that also acts faster than traditional therapies, which can take weeks to show any appreciable effect. 

Low-dose ketamine can have a very rapid effect with rare physical dependence and relatively few unpleasant side effects. Repeated doses of ketamine at an appropriate interval may be beneficial not only in staving off suicidal thoughts, but also in treating Bipolar’s notoriously resistant depressive episodes. 

Preliminary data suggest that ketamine may be an effective alternative in the treatment of PTSDOne study found that ketamine therapy was associated with a “significant and rapid reduction in PTSD symptom severity, compared with midazolam, when assessed 24 hours after infusion.”

Another interesting case study described a patient who was given ketamine therapy for treatment-resistant Major Depressive Disorder. The ketamine had the unexpected benefit of temporarily resolving the patient’s PTSD symptoms as well.

2018 study in Australia found that oral ketamine is given in an outpatient setting, such as a physician’s office, reduced psychiatric hospital admissions for depression and PTSD by approximately 70 percent per patient. Both the number of admissions and the length of stay were reduced.

With more investigation, ketamine may prove to be an effective alternative to patients who have continued to experience symptoms of PTSD with conventional therapies. If you are experiencing persistent symptoms of PTSD, we encourage you to discuss treatment options with your doctor.

The effect of Ketamine on some anxiety symptoms can be appreciated in mere hours. Ongoing side effects are generally  minimal and usually do not include the bothersome adverse events associated with many traditional antidepressants (sleep disturbances, weight gain, fatigue, constipation, diarrhea, and others). Additionally, Ketamine is not physically addicting, so there is no need to wean off the medication when it is used appropriately.

The exact mechanism of action that allows ketamine to work so quickly is still under investigation. However, it appears to produce anti-anxiety effects by acting on the brain’s NMDA receptor. This receptor is in the family of L-glutamate receptors. Glutamate is thought to be crucial in mediating the stress response and the formation of traumatic memories. 

Individuals with OCD are often plagued by repetitive, unwanted thoughts. In an effort to suppress these thoughts, OCD patients often perform “rituals.” These are repetitive tasks meant to soothe and distract, such as handwashing and counting. People with OCD may experience a dramatic increase in anxiety if they are unable to perform their rituals. 

Studies for the treatment of OCD using ketamine are in the early stages. However, they have shown promising results, with one study reporting “rapid, sustained therapeutic effects in OCD patients.”

Ketamine has been approved by the FDA for the treatment of drug-resistant depression and acute suicidal ideation. However, recent studies support its use for a wide variety of mental health disorders, including those related to chronic pain

In sub-anesthetic doses, ketamine has been shown especially to have a positive effect on neuropathic pain conditions, such as chronic regional pain syndrome (CRPS) and post-herpetic neuralgia. Animal studies have confirmed ketamine’s efficacy in treating neuropathic pain disorders, in part, due to a unique ability to inhibit microglial activation and neuronal inflammation. 

As the primary immune cells of the central nervous system, microglial cells play a crucial role in infection and inflammation in the brain. Suppressing this inflammation response may be one reason why ketamine is able to alleviate nerve pain so successfully. 

Depression

Ketamine interacts with neurotransmitter glutamate as a dissociative agent. The effect on serotonin and the opiate system is also downfield. Research has shown that it can significantly reduce suicidal thoughts in 24 hours.

 

Bipolar Disorder

Of all mental health disorders, bipolar disorder has one of the highest lifetime risks of suicide. Ketamine has been approved for the treatment of acute suicidal ideation, which means it may be appropriate for bipolar patients. 

 

PTSD

Preliminary data suggest that ketamine may be an effective alternative in the treatment of PTSDOne study found that ketamine therapy was associated with a “significant and rapid reduction in PTSD symptom severity, compared with midazolam, when assessed 24 hours after infusion.”

 

Anxiety Disorders

The effect of Ketamine on some anxiety symptoms can be appreciated in mere hours. Ongoing side effects are generally  minimal and usually do not include the bothersome adverse events associated with many traditional antidepressants (sleep disturbances, weight gain, fatigue, constipation, diarrhea, and others).

OCD

Studies for the treatment of OCD using ketamine are in the early stages. However, they have shown promising results, with one study reporting “rapid, sustained therapeutic effects in OCD patients.”

woman rubbing sore neck
Chronic Pain

Ketamine has been approved by the FDA for the treatment of drug-resistant depression and acute suicidal ideation. However, recent studies support its use for a wide variety of mental health disorders, including those related to chronic pain